EXTH-17. LOCAL DELIVERY OF CYTOKINES AND SYNTHETIC IMMUNOMODULATORS INCREASES T CELL INFILTRATION AND SIGNIFICANTLY IMPROVES SURVIVAL IN A POORLY IMMUNOGENIC MODEL OF GLIOBLASTOMA

BACKGROUND: Severe local and systemic immune suppression in glioblastoma (GBM) contributes to the failure of single-agent immunotherapies in clinical trials. In this study, we evaluated the efficacy of locally delivered combination immunotherapy in a poorly immunogenic murine GBM model. METHODS: Imm...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Haddad, Alexander, Spatz, Jordan, Collins, Sara, Pereira, Matheus, Gill, Sabraj, Montoya, Megan, Chuntova, Polly, Young, Jacob, Mummaneni, Nikhil, Kasahara, Noriyuki, Aghi, Manish
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Preclinical Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651711/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.371
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