EXTH-10. COMBINATION OF EPIGENETIC ENZYME INHIBITORS, GSK-J4 AND BELINOSTAT, REVEALS HIGH EFFICACY IN IDH1 MUTANT GLIOMAS

Mutations in IDH1 and IDH2 genes are common in low grade gliomas and secondary GBM and are known to cause a distinct epigenetic landscape in these tumors. To interrogate the epigenetic vulnerabilities of IDH-mutant gliomas, we performed a chemical screen with inhibitors of chromatin modifiers and id...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Kayabolen, Alisan, Sahin, Gizem Nur, Seker, Fidan, Cingoz, Ahmet, Isik, Bekir, Acar, Simge, Wakimoto, Hiroaki, Cahill, Daniel, Solaroglu, Ihsan, Cribbs, Adam, Oppermann, Udo, Bagci-Onder, Tugba
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Preclinical Experimental Therapeutics
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651554/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.364
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items