EXTH-10. COMBINATION OF EPIGENETIC ENZYME INHIBITORS, GSK-J4 AND BELINOSTAT, REVEALS HIGH EFFICACY IN IDH1 MUTANT GLIOMAS

Mutations in IDH1 and IDH2 genes are common in low grade gliomas and secondary GBM and are known to cause a distinct epigenetic landscape in these tumors. To interrogate the epigenetic vulnerabilities of IDH-mutant gliomas, we performed a chemical screen with inhibitors of chromatin modifiers and id...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Kayabolen, Alisan, Sahin, Gizem Nur, Seker, Fidan, Cingoz, Ahmet, Isik, Bekir, Acar, Simge, Wakimoto, Hiroaki, Cahill, Daniel, Solaroglu, Ihsan, Cribbs, Adam, Oppermann, Udo, Bagci-Onder, Tugba
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Preclinical Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651554/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.364
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