DDRE-18. DEVELOPMENT OF EGFRvIII AND EGFR DIRECTED CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME

BACKGROUND: Chimeric antigen receptor T cell (CART) therapy has revolutionized the treatment landscape for hematological malignancies, its efficacy remains limited in solid tumors. EGFRvIII is a truncated version of the wild type EGFR in which deletion of exons 2–7 of the extracellular domain leads...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Ruff, Michael, Sakemura, Reona, Manriquez-Roman, Claudia, Hefazi-Torghabeh, Mehrdad, Schick, Kendall, Michelle, Cox, Can, Ismail, Horvei, Paulina, Siegler, Elizabeth, Tapper, Erin, Kenderian, Saad
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Drug Discovery, Drug Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651519/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.263
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