EXTH-32. DEVELOPMENT OF EPHA3 DIRECTED CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME

BACKGROUND: Efficacy of chimeric antigen receptor T cell (CART) therapy remains limited in solid tumors. Given the heterogeneity of surface receptor expression and immunosuppressive stromal microenvironment, strategies to target tumor neovasculature and tumor stromal cells are needed to help overcom...

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Publicado en:Neuro Oncol
Autores principales: Ruff, Michael, Sakemura, Reona, Cox, Michelle, Hefazi Torghabeh, Mehrdad, Roman Moreno, Paulina, Schick, Kendall, Sarkaria, Jann, Kenderian, Saad
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847906/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.364
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