EXTH-32. DEVELOPMENT OF EPHA3 DIRECTED CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME

BACKGROUND: Efficacy of chimeric antigen receptor T cell (CART) therapy remains limited in solid tumors. Given the heterogeneity of surface receptor expression and immunosuppressive stromal microenvironment, strategies to target tumor neovasculature and tumor stromal cells are needed to help overcom...

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Vydáno v:Neuro Oncol
Hlavní autoři: Ruff, Michael, Sakemura, Reona, Cox, Michelle, Hefazi Torghabeh, Mehrdad, Roman Moreno, Paulina, Schick, Kendall, Sarkaria, Jann, Kenderian, Saad
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847906/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.364
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