TAMI-52. G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS’-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT

Mutation in isocitrate dehydrogenase (mIDH) is the main genetic lesion that defines clinical glioma subtypes and prognosis. This gain of function mutation is associated with the production of the oncometabolite, R-2-hydroxyglutarate, that inhibits α-ketoglutarate dependent enzymes such as TET2 and t...

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Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Alghamri, Mahmoud, Avvari, Ruthvik, Thalla, Rohit, Zhang, Li, Ventosa, Maria, Taher, Ayman, Núñez, Felipe, Heth, Jason, Orringer, Daniel, Lowenstein, Pedro, Castro, Maria
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651463/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.939
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