EPCO-35. SINGLE-CELL RNA-SEQ OF PEDIATRIC EPENDYMOMA REVEALS PROGNOSTIC IMPACT OF IMPAIRED NEURONAL-GLIAL FATE SPECIFICATION

Ependymoma represents a heterogeneous disease affecting the entire neuraxis. Extensive molecular profiling efforts have identified molecular ependymoma subgroups based on DNA methylation. However, the intratumoral heterogeneity and developmental origins of these groups are only partially understood,...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Englinger, Bernhard, Gojo, Johannes, Jiang, Li, Hübner, Jens M, Shaw, McKenzie, Hack, Olivia, Liu, Ilon, Madlener, Sibylle, Kirchhofer, Dominik, Pyrdol, Jason, Hovestadt, Volker, Mazzola, Emanuele, Mathewson, Nathan, Trissal, Maria, Lötsch, Daniela, Dorfer, Christian, Haberler, Christine, Halfmann, Angela, Mayr, Lisa, Peyrl, Andreas, Geyeregger, Rene, Schwalm, Benjamin, Mauermann, Monica, Pajtler, Kristian, Milde, Till, Shore, Marni, Geduldig, Jack, Pelton, Kristine, Czech, Thomas, Ashenberg, Orr, Wucherpfennig, Kai, Rozenblatt-Rosen, Orit, Alexandrescu, Sanda, Ligon, Keith, Pfister, Stefan, Regev, Aviv, Slavc, Irene, Berger, Walter, Suva, Mario, Kool, Marcel, Filbin, Mariella
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
(Epi)Genetics and Computational Omics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651434/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.314
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