EXTH-35. SYNERGISTIC EFFECT OF TARGETING THIOREDOXIN REDUCTASE (TRX1) AND DEPLETION OF GLUTATHIONE SYSTEM (GSH) IN GLIOBLASTOMA STEM CELLS

Glioblastoma (GBM), the most common and advanced malignant primary brain tumor in adults remains incurable. GBM tumor recurrence occurs within a short time reflecting the failure to eradicate chemo-radioresistant GBM stem cells (GSCs). GSCs alter the redox system including Thioredoxin (Trx) and glut...

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Vydáno v:Neuro Oncol
Hlavní autoři: Jamali, Fatemeh, Daniel, Paul, Petrecca, Kevin, Abdulkarim, Bassam, Sabri, Siham
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Preclinical Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651382/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.389
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