IMMU-20. SINGLE-CELL RNASEQ OF TUMOR INFILTRATING IMMUNE CELLS FROM NEOADJUVANT ANTI-PD1 TREATED GBM PATIENTS REVEALS GLOBAL TRANSCRIPTIONAL CHANGES AND IMMUNOSUPPRESSIVE ADAPTIVE RESPONSES BY MYELOID CELLS

INTRODUCTION: Neoadjuvant anti-PD1 therapy (neo-aPD1) was previously shown to significantly increase the survival of recurrent glioblastoma patients in a small randomized clinical trial. However, neo-aPD1 alone was not curative so defining the limitations of neo-aPD1 and discovering where other immu...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Lee, Alexander, Mochizuki, Aaron, Chow, Frances, Reynoso, Jeremy, Orpilla, Joey, Sun, Lu, Chavez, Carolina, Galvez, Mildred, Kienzler, Jenny, Yong, William, Everson, Richard, Nathanson, David, Bensinger, Steven, Liau, Linda, Cloughesy, Timothy, Hugo, Willy, Prins, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651260/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.450
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