EXTH-29. INHIBITION OF LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A (KDM1A/LSD1) SENSITIZES GLIOBLASTOMA CELLS TO CHEMO AND RADIATION THERAPY

BACKGROUND: Despite treatment advances, glioblastoma (GBM) is the deadliest tumor of the central nervous system. Patients face a dismal 15-month median survival and average 5-year survival rate of 13%. Current standard of care includes surgical resection, external beam radiation therapy, and adjuvan...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Alejo, Salvador, Palacios, Bridgitte, Venkata, Prabhakar Pitta, Chen, Yihong, He, Yi, Viswanadhapalli, Suryavathi, Pratap, Uday, Zheng, Siyuan, Brenner, Andrew, Vadlamudi, Ratna, Sareddy, Gangadhara
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
Soggetti:
Preclinical Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651145/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.383
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