TAMI-38. CYSTEINE-PROMOTING COMPOUNDS INDUCE MITOCHONDRIAL TOXICITY IN GLIOBLASTOMA THROUGH ALTERED PYRUVATE AND SERINE METABOLISM

Glioblastoma (GBM) remains a poorly treatable disease with high mortality. Tumor metabolism in GBM is a critical mechanism responsible for accelerated growth because of upregulation of glucose, amino acid, and fatty acid utilization. However, little is known about the metabolic alterations that are...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Noch, Evan, Palma, Laura, Yim, Isaiah, Binder, Bhavneet, Benedetti, Elisa, Krumsiek, Jan, Elemento, Olivier, Cantley, Lewis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Tumor Microenvironment/Angiogenesis/Metabolism/Invasion
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651089/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.926
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