CTIM-21. PEPTIDE VACCINE DIRECTED TO CMV pp65 FOR TREATMENT OF RECURRENT MALIGNANT GLIOMA AND MEDULLOBLASTOMA IN CHILDREN AND YOUNG ADULTS: PRELIMINARY RESULTS OF A PHASE I TRIAL

INTRODUCTION: The cytomegalovirus (CMV) antigen, pp65, is ubiquitously expressed in malignant glioma and medulloblastoma but not in healthy brain. The objective of this Phase I trial (NCT03299309) was to assess the safety and feasibility of a novel pp65 peptide vaccine (PEP-CMV) in children and youn...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Thompson, Eric, Landi, Daniel, Lipp, Eric, Balajonda, Bea, Herndon, James, Buckley, Evan, Flahiff, Charlene, Jaggers, Denise, Schroeder, Kristin, Randazzo, Dina, Desjardins, Annick, Johnson, Maggie, Peters, Katherine, Khasraw, Mustafa, Malinzak, Michael, Mitchell, Duane, Ashley, David, Sampson, John
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Clinical Trials: Immunologic
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650420/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.155
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