CTNI-31. INTERIM RESULTS OF A PHASE I/IIA STUDY TO EVALUATE THE SAFETY AND EFFICACY OF BBB OPENING WITH THE SONOCLOUD-9 IMPLANTABLE ULTRASOUND DEVICE IN RECURRENT GLIOBLASTOMA PATIENTS PRIOR TO IV CARBOPLATIN

Low intensity pulsed ultrasound (LIPU), in combination with systemic injection of microbubbles, can be used to transiently disrupt the blood-brain barrier (BBB) and increase brain-drug concentrations. In pre-clinical models, carboplatin can be enhanced by a factor of 5x in the brain using LIPU and i...

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Publicat a:Neuro Oncol
Autors principals: Idbaih, Ahmed, Ducray, François, Stupp, Roger, Baize, Nathalie, Chinot, Olivier, de Groot, John, Guyotat, Jacques, Sonabend, Adam, Menei, Philippe, Dufour, Henry, Weinberg, Jeffrey, Desseaux, Carole, Canney, Michael, Schmitt, Charlotte, Carpentier, Alexandre
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Clinical Trials: Non-Immunologic
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650399/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.198
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