CTNI-31. INTERIM RESULTS OF A PHASE I/IIA STUDY TO EVALUATE THE SAFETY AND EFFICACY OF BBB OPENING WITH THE SONOCLOUD-9 IMPLANTABLE ULTRASOUND DEVICE IN RECURRENT GLIOBLASTOMA PATIENTS PRIOR TO IV CARBOPLATIN

Low intensity pulsed ultrasound (LIPU), in combination with systemic injection of microbubbles, can be used to transiently disrupt the blood-brain barrier (BBB) and increase brain-drug concentrations. In pre-clinical models, carboplatin can be enhanced by a factor of 5x in the brain using LIPU and i...

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書目詳細資料
發表在:Neuro Oncol
Main Authors: Idbaih, Ahmed, Ducray, François, Stupp, Roger, Baize, Nathalie, Chinot, Olivier, de Groot, John, Guyotat, Jacques, Sonabend, Adam, Menei, Philippe, Dufour, Henry, Weinberg, Jeffrey, Desseaux, Carole, Canney, Michael, Schmitt, Charlotte, Carpentier, Alexandre
格式: Artigo
語言:Inglês
出版: Oxford University Press 2020
主題:
Clinical Trials: Non-Immunologic
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650399/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.198
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