CTIM-11. PHASE I/II STUDY TO EVALUATE THE SAFETY AND CLINICAL EFFICACY OF ATEZOLIZUMAB (ATEZO) IN COMBINATION WITH TEMOZOLOMIDE (TMZ) AND RADIATION IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA (GBM)

BACKGROUND: Immunotherapy strategies such as PD-1/PD-L1 inhibition may work synergistically with radiation, which is known to increase antigen presentation and promote a pro-inflammatory tumor microenvironment. This trial evaluated the safety and clinical efficacy of concurrent atezo (anti-PD-L1) wi...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Weathers, Shiao-Pei, Kamiya-Matsuoka, Carlos, Harrison, Rebecca, Liu, Diane, Sanqui, Edmund, Dervin, Shannon, Yun, Cindy, Loghin, Monica, Penas-Prado, Marta, Majd, Nazanin, Yung, W K Alfred, O’Brien, Barbara, de Groot, John
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Clinical Trials: Immunologic
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650346/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.145
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