CTNI-01. EFFECT OF STEREOTACTIC RADIOSURGERY COMPARED TO WHOLE-BRAIN RADIOTHERAPY FOR LIMITED BRAIN METASTASIS ON LONG TERM COGNITION AND QUALITY OF LIFE: A POOLED ANALYSIS OF RANDOMIZED CLINICAL TRIALS

PURPOSE: We investigated the long term impact of SRS and WBRT in two large prospective phase III trials. METHODS: Patients with 1–4 BMs +/- resection were randomized to SRS or WBRT. Cognitive deterioration was a drop of >1 standard deviation from baseline in >2/6 cognitive measures (CM). Quali...

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Vydáno v:Neuro Oncol
Hlavní autoři: Palmer, Joshua, Klamer, Brett, Ballman, Karla, Brown, Paul, Cerhan, Jane, Anderson, S Keith, Whitton, Anthony, Greenspoon, Jeffrey, Chung, Caroline, Burri, Stuart, Parney, Ian, Stieber, Volker, Pollock, Bruce, Laack, Nadia, Ashman, Jonathon, Bahary, Jean-Paul, Barker, Fred, Galanis, Evanthia, Asher, Anthony, Roberge, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Clinical Trials: Non-Immunologic
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650320/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.168
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