Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial

IMPORTANCE: Whole brain radiotherapy (WBRT) significantly improves tumor control in the brain after stereotactic radiosurgery (SRS), yet because of its association with cognitive decline, its role in the treatment of patients with brain metastases remains controversial. OBJECTIVE: To determine wheth...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Brown, Paul D., Jaeckle, Kurt, Ballman, Karla V., Farace, Elana, Cerhan, Jane H., Anderson, S. Keith, Carrero, Xiomara W., Barker, Fred G., Deming, Richard, Burri, Stuart H., Ménard, Cynthia, Chung, Caroline, Stieber, Volker W., Pollock, Bruce E., Galanis, Evanthia, Buckner, Jan C., Asher, Anthony L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5313044/
https://ncbi.nlm.nih.gov/pubmed/27458945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2016.9839
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