Replication stress at microsatellites causes DNA double-strand breaks and break-induced replication

Short tandemly repeated DNA sequences, termed microsatellites, are abundant in the human genome. These microsatellites exhibit length instability and susceptibility to DNA double-strand breaks (DSBs) due to their tendency to form stable non-B DNA structures. Replication-dependent microsatellite DSBs...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Gadgil, Rujuta Yashodhan, Romer, Eric J., Goodman, Caitlin C., Rider, S. Dean, Damewood, French J., Barthelemy, Joanna R., Shin-ya, Kazuo, Hanenberg, Helmut, Leffak, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
Soggetti:
DNA and Chromosomes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650239/
https://ncbi.nlm.nih.gov/pubmed/32873711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013495
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