Radiosynthesis and evaluation of 4-(6-[(18)F]Fluoro-4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine as a novel radiotracer candidate targeting leucine-rich repeat kinase 2

Mutations that increase leucine-rich repeat kinase 2 (LRRK2) activity in the brain are associated with Parkinson's disease. Here, we synthesized a novel compound 4-(6-fluoro-4-(5-isopropoxy-1H-indazol-3-yl)pyridin-2-yl)morpholine (FIPM) and labeled it with fluorine-18 ((18)F), to develop a posi...

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Detalles Bibliográficos
Publicado en:RSC Med Chem
Main Authors: Mori, Wakana, Yamasaki, Tomoteru, Hattori, Yasushi, Zhang, Yiding, Kumata, Katsushi, Fujinaga, Masayuki, Hanyu, Masayuki, Nengaki, Nobuki, Zhang, Hong, Zhang, Ming-Rong
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2020
Assuntos:
Chemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649847/
https://ncbi.nlm.nih.gov/pubmed/33479667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00590k
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