Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome

BACKGROUND: Severe early-onset erythroderma and gut inflammation, with massive tissue infiltration of oligoclonal activated T cells are the hallmark of Omenn syndrome (OS). OBJECTIVE: The impact of altered gut homeostasis in the cutaneous manifestations of OS remains to be clarified. METHODS: We ana...

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Bibliografiske detaljer
Udgivet i:J Allergy Clin Immunol
Main Authors: Rigoni, Rosita, Fontana, Elena, Dobbs, Kerry, Marrella, Veronica, Taverniti, Valentina, Maina, Virginia, Facoetti, Amanda, D’Amico, Giovanna, Al-Herz, Waleed, Cruz-Munoz, Mario Ernesto, Schuetz, Catharina, Gennery, Andrew R., Garabedian, Elizabeth K., Giliani, Silvia, Draper, Deborah, Dbaibo, Ghassan, Geha, Raif S., Meyts, Isabelle, Tousseyn, Thomas, Neven, Benedicte, Moshous, Despina, Fischer, Alain, Schulz, Ansgar, Finocchi, Andrea, Kuhns, Douglas B., Fink, Danielle L., Lionakis, Michail S., Swamydas, Muthulekha, Guglielmetti, Simone, Alejo, Julie, Myles, Ian A., Pittaluga, Stefania, Notarangelo, Luigi D., Villa, Anna, Cassani, Barbara
Format: Artigo
Sprog:Inglês
Udgivet: Mosby 2020
Fag:
Translational and Clinical Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649331/
https://ncbi.nlm.nih.gov/pubmed/32311393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.04.005
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