Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome

BACKGROUND: Severe early-onset erythroderma and gut inflammation, with massive tissue infiltration of oligoclonal activated T cells are the hallmark of Omenn syndrome (OS). OBJECTIVE: The impact of altered gut homeostasis in the cutaneous manifestations of OS remains to be clarified. METHODS: We ana...

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Detalles Bibliográficos
Publicado en:J Allergy Clin Immunol
Main Authors: Rigoni, Rosita, Fontana, Elena, Dobbs, Kerry, Marrella, Veronica, Taverniti, Valentina, Maina, Virginia, Facoetti, Amanda, D’Amico, Giovanna, Al-Herz, Waleed, Cruz-Munoz, Mario Ernesto, Schuetz, Catharina, Gennery, Andrew R., Garabedian, Elizabeth K., Giliani, Silvia, Draper, Deborah, Dbaibo, Ghassan, Geha, Raif S., Meyts, Isabelle, Tousseyn, Thomas, Neven, Benedicte, Moshous, Despina, Fischer, Alain, Schulz, Ansgar, Finocchi, Andrea, Kuhns, Douglas B., Fink, Danielle L., Lionakis, Michail S., Swamydas, Muthulekha, Guglielmetti, Simone, Alejo, Julie, Myles, Ian A., Pittaluga, Stefania, Notarangelo, Luigi D., Villa, Anna, Cassani, Barbara
Formato: Artigo
Idioma:Inglês
Publicado: Mosby 2020
Assuntos:
Translational and Clinical Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7649331/
https://ncbi.nlm.nih.gov/pubmed/32311393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2020.04.005
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