Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics

Gene expression is thought to be affected not only by the concentration of transcription factors (TFs) but also the dynamics of their nuclear translocation. Testing this hypothesis requires direct control of TF dynamics. Here, we engineer CLASP, an optogenetic tool for rapid and tunable translocatio...

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Publicat a:Cell Syst
Autors principals: Chen, Susan Y., Osimiri, Lindsey C., Chevalier, Michael, Bugaj, Lukasz J., Nguyen, Taylor H., Greenstein, R.A., Ng, Andrew H., Stewart-Ornstein, Jacob, Neves, Lauren T., El-Samad, Hana
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648432/
https://ncbi.nlm.nih.gov/pubmed/32898473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.08.009
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