Interleukin-34 Limits the Therapeutic Effects of Immune Checkpoint Blockade

Interleukin-34 (IL-34) is an alternative ligand to colony-stimulating factor-1 (CSF-1) for the CSF-1 receptor that acts as a key regulator of monocyte/macrophage lineage. In this study, we show that tumor-derived IL-34 mediates resistance to immune checkpoint blockade regardless of CSF-1 existence i...

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Publicat a:iScience
Autors principals: Hama, Naoki, Kobayashi, Takuto, Han, Nanumi, Kitagawa, Fumihito, Kajihara, Nabeel, Otsuka, Ryo, Wada, Haruka, Lee, Hee-kyung, Rhee, Hwanseok, Hasegawa, Yoshinori, Yagita, Hideo, Baghdadi, Muhammad, Seino, Ken-ichiro
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7648133/
https://ncbi.nlm.nih.gov/pubmed/33205010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101584
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