Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

Antigen (Ag)-presenting cells (APC) instruct CD4+ helper T (Th) cell responses, but it is unclear whether different APC subsets contribute uniquely in determining Th differentiation in pathogen-specific settings. Here, we use skin-relevant, fluorescently-labeled bacterial, helminth or fungal pathoge...

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發表在:Nat Commun
Main Authors: Hilligan, Kerry L., Tang, Shiau-Choot, Hyde, Evelyn J., Roussel, Elsa, Mayer, Johannes U., Yang, Jianping, Wakelin, Kirsty A., Schmidt, Alfonso J., Connor, Lisa M., Sher, Alan, MacDonald, Andrew S., Ronchese, Franca
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647995/
https://ncbi.nlm.nih.gov/pubmed/33159073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19463-9
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