Untenable Dosing: A Common Pitfall of Modern DLT-targeting Phase I Designs in Oncology

BACKGROUND: There is increasing use of Phase I statistical designs to find a dose that causes rapidly emerging and particularly concerning severe or life-threatening toxicities (DLTs) in a specified percent of patients, most commonly 25%. While a convenient statistical framework, the foundation for...

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Udgivet i:Curr Probl Cancer
Main Authors: Frankel, Paul H., Chung, Vincent, Xing, Yan, Longmate, Jeff, Groshen, Susan, Newman, Edward M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7647940/
https://ncbi.nlm.nih.gov/pubmed/32446637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.currproblcancer.2020.100583
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