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Untenable Dosing: A Common Pitfall of Modern DLT-targeting Phase I Designs in Oncology
BACKGROUND: There is increasing use of Phase I statistical designs to find a dose that causes rapidly emerging and particularly concerning severe or life-threatening toxicities (DLTs) in a specified percent of patients, most commonly 25%. While a convenient statistical framework, the foundation for...
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| Izdano u: | Curr Probl Cancer |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7647940/ https://ncbi.nlm.nih.gov/pubmed/32446637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.currproblcancer.2020.100583 |
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