MicroRNA-494 suppresses hypoxia/reoxygenation-induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1

Acute myocardial infarction can be caused by ischemia/reperfusion (I/R) injury; however, the mechanism underlying I/R is not completely understood. The present study investigated the functions and mechanisms underlying microRNA (miR)-494 in I/R-induced cardiomyocyte apoptosis and autophagy. Hypoxia/...

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Pubblicato in:Mol Med Rep
Autori principali: Ning, Shuwei, Li, Zhiying, Ji, Zhenyu, Fan, Dandan, Wang, Keke, Wang, Qian, Hua, Lei, Zhang, Junyue, Meng, Xiangguang, Yuan, Yiqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7646990/
https://ncbi.nlm.nih.gov/pubmed/33174056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.11636
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