Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation.

BACKGROUND; Previous studies have demonstrated that the A1A2A3 domains of VWF play a key role in regulating macrophage-mediated clearance in-vivo. In particular, the A1-domain has been shown to modulate interaction with macrophage LRP1 clearance receptor. Furthermore, N-linked glycans within the A2-...

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Bibliographic Details
Published in:J Thromb Haemost
Main Authors: Fazavana, Judicael, Brophy, Teresa M., Chion, Alain, Cooke, Niamh, Terraube, Virginie, Cohen, Justin, Parng, Chuenlei, Pittman, Debra, Cunningham, Orla, Lambert, Matthew, O’Donnell, James S., O’Sullivan, Jamie M.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645976/
https://ncbi.nlm.nih.gov/pubmed/32108991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14785
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