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Autofluorescence-based sorting removes senescent cells from mesenchymal stromal cell cultures

Mesenchymal stromal cells (MSC) are used in cell therapy, but results depend on the unknown quality of cell populations. Extended culture time of MSC increases their senescent levels, leading to a critical loss of cell fitness. Here, we tested the suitability of MSC-sorting based on their FACS autof...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bertolo, Alessandro, Guerrero, Julien, Stoyanov, Jivko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645702/
https://ncbi.nlm.nih.gov/pubmed/33154552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76202-2
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