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LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regulators in...

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Bibliografische gegevens
Gepubliceerd in:EMBO Mol Med
Hoofdauteurs: Leiendecker, Lukas, Jung, Pauline S, Krecioch, Izabela, Neumann, Tobias, Schleiffer, Alexander, Mechtler, Karl, Wiesner, Thomas, Obenauf, Anna C
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645387/
https://ncbi.nlm.nih.gov/pubmed/33026191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012525
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