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LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regulators in...

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Detalles Bibliográficos
Publicado en:EMBO Mol Med
Autores principales: Leiendecker, Lukas, Jung, Pauline S, Krecioch, Izabela, Neumann, Tobias, Schleiffer, Alexander, Mechtler, Karl, Wiesner, Thomas, Obenauf, Anna C
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645387/
https://ncbi.nlm.nih.gov/pubmed/33026191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012525
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