Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells

PURPOSE: The lamina cribrosa (LC) is a key site of damage in glaucomatous optic neuropathy. We previously found that glaucoma LC cells have an increased profibrotic gene expression, with mitochondrial dysfunction in the form of decreased mitochondrial membrane potential. Altered cell bioenergetics h...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Kamel, Khalid, O'Brien, Colm J., Zhdanov, Alexander V., Papkovsky, Dmitri B., Clark, Abbot F., Stamer, Daniel, Irnaten, Mustapha
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2020
Fag:
Glaucoma
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7645202/
https://ncbi.nlm.nih.gov/pubmed/33137197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.13.4
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