Lipofuscin accumulation and autophagy in glaucomatous human lamina cribrosa cells

BACKGROUND: Disease associated alterations in the phenotype of lamina cribrosa (LC) cells are implicated in changes occurring at the optic nerve head (ONH) in glaucoma. Lipofuscin, the formation of which is driven by reactive oxygen species (ROS), is an intralysosomal, non-degradable, auto-fluoresce...

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Detalhes bibliográficos
Publicado no:BMC Ophthalmol
Main Authors: McElnea, Elizabeth M, Hughes, Emily, McGoldrick, Aloysius, McCann, Amanda, Quill, Barry, Docherty, Neil, Irnaten, Mustapha, Farrell, Michael, Clark, Abbot F, O’Brien, Colm J, Wallace, Deborah M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265474/
https://ncbi.nlm.nih.gov/pubmed/25444463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2415-14-153
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