Circumventing colistin resistance by combining colistin and antimicrobial peptides to kill colistin-resistant and multidrug-resistant Gram-negative bacteria

OBJECTIVES: Colistin is a ‘last-line’ antibiotic used to treat multidrug-resistant Gram-negative bacteria, but colistin resistance has emerged. Colistin normally binds to the lipid A moiety on the bacterial outer membrane, where it then destroys the bacterial membrane. Mobilize colistin resistance (...

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Veröffentlicht in:J Glob Antimicrob Resist
Hauptverfasser: Witherell, Kaitlin S., Price, Jason, Bandaranayake, Ashok D., Olson, James, Call, Douglas R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644326/
https://ncbi.nlm.nih.gov/pubmed/32512236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jgar.2020.05.013
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