RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development

The characterization of prostate epithelial hierarchy and lineage heterogeneity is critical to understand its regenerative properties and malignancies. Here, we report that the transcription factor RUNX1 marks a specific subpopulation of proximal luminal cells (PLCs), enriched in the periurethral re...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Mevel, Renaud, Steiner, Ivana, Mason, Susan, Galbraith, Laura CA, Patel, Rahima, Fadlullah, Muhammad ZH, Ahmad, Imran, Leung, Hing Y, Oliveira, Pedro, Blyth, Karen, Baena, Esther, Lacaud, Georges
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644213/
https://ncbi.nlm.nih.gov/pubmed/33025905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60225
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