All-trans retinoic acid in non-promyelocytic acute myeloid leukemia: driver lesion dependent effects on leukemic stem cells

Acute myeloid leukemia (AML) is an aggressive, often fatal hematopoietic malignancy. All-trans retinoic acid (atRA), one of the first molecularly targeted drugs in oncology, has greatly improved the outcome of a subtype of AML, acute promyelocytic leukemia (APL). In contrast, atRA has so far provide...

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Udgivet i:Cell Cycle
Main Authors: Nguyen, Chi H., Grandits, Alexander M., Purton, Louise E., Sill, Heinz, Wieser, Rotraud
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644151/
https://ncbi.nlm.nih.gov/pubmed/32900260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1810402
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