Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

Interferons (IFNs) are cytokines that are central to the host defence against viruses and other microorganisms. If not properly regulated, IFNs may contribute to the pathogenesis of inflammatory autoimmune, or infectious diseases. To identify genetic polymorphisms regulating the IFN system we perfor...

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Pubblicato in:PLoS Genet
Autori principali: Lundtoft, Christian, Pucholt, Pascal, Imgenberg-Kreuz, Juliana, Carlsson-Almlöf, Jonas, Eloranta, Maija-Leena, Syvänen, Ann-Christine, Nordmark, Gunnel, Sandling, Johanna K., Kockum, Ingrid, Olsson, Tomas, Rönnblom, Lars, Hagberg, Niklas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644105/
https://ncbi.nlm.nih.gov/pubmed/33104735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009199
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