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Gene expression noise can promote the fixation of beneficial mutations in fluctuating environments

Nongenetic phenotypic variation can either speed up or slow down adaptive evolution. We show that it can speed up evolution in environments where available carbon and energy sources change over time. To this end, we use an experimentally validated model of Escherichia coli growth on two alternative...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: Schmutzer, Michael, Wagner, Andreas
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644098/
https://ncbi.nlm.nih.gov/pubmed/33104710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007727
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