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Rituximab-specific DNA aptamers are able to selectively recognize heat-treated antibodies

The monoclonal anti-CD20 IgG1 antibody rituximab is used as a first-line treatment for B cell lymphoma. Like all therapeutic antibodies, it is a complex protein for which both safety and efficacy heavily depend on the integrity of its three-dimensional structure. Aptamers, short oligonucleotides wit...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Kohlberger, Michael, Wildner, Sabrina, Regl, Christof, Huber, Christian G., Gadermaier, Gabriele
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644011/
https://ncbi.nlm.nih.gov/pubmed/33151990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0241560
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