The HB22.7–vcMMAE antibody–drug conjugate has efficacy against non-Hodgkin lymphoma mouse xenografts with minimal systemic toxicity

In this study, HB22.7, an anti-CD22 monoclonal antibody, was used for specific, targeted delivery of monomethyl auristatin E (MMAE) to non-Hodgkin lymphoma (NHL). MMAE was covalently coupled to HB22.7 through a valine–citrulline peptide linker (vc). Maleimide-functionalized vcMMAE (mal-vcMMAE) was r...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Abuhay, Mastewal, Kato, Jason, Tuscano, Emily, Barisone, Gustavo A., Sidhu, Ranjit S., O’Donnell, Robert T., Tuscano, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643839/
https://ncbi.nlm.nih.gov/pubmed/27506529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1873-y
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