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Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011‐vcMMAE antibody‐drug conjugate
GPNMB is a melanoma‐associated glycoprotein that is targeted by the CR011‐vcMMAE antibody‐drug conjugate (ADC). Previous studies have shown that CR011‐vcMMAE induces the apoptosis of GPNMB‐expressing tumor cells in vitro and tumor regression in xenograft models. This ADC is currently in clinical tri...
Gespeichert in:
| Veröffentlicht in: | Mol Oncol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5527796/ https://ncbi.nlm.nih.gov/pubmed/19383330 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2008.02.002 |
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