Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011‐vcMMAE antibody‐drug conjugate

GPNMB is a melanoma‐associated glycoprotein that is targeted by the CR011‐vcMMAE antibody‐drug conjugate (ADC). Previous studies have shown that CR011‐vcMMAE induces the apoptosis of GPNMB‐expressing tumor cells in vitro and tumor regression in xenograft models. This ADC is currently in clinical tri...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Oncol
Hauptverfasser: Qian, Xiaozhong, Mills, Evan, Torgov, Michael, LaRochelle, William J., Jeffers, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2008
Schlagworte:
Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527796/
https://ncbi.nlm.nih.gov/pubmed/19383330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2008.02.002
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge