Pharmacologically enhanced expression of GPNMB increases the sensitivity of melanoma cells to the CR011‐vcMMAE antibody‐drug conjugate

GPNMB is a melanoma‐associated glycoprotein that is targeted by the CR011‐vcMMAE antibody‐drug conjugate (ADC). Previous studies have shown that CR011‐vcMMAE induces the apoptosis of GPNMB‐expressing tumor cells in vitro and tumor regression in xenograft models. This ADC is currently in clinical tri...

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Опубликовано в: :Mol Oncol
Главные авторы: Qian, Xiaozhong, Mills, Evan, Torgov, Michael, LaRochelle, William J., Jeffers, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527796/
https://ncbi.nlm.nih.gov/pubmed/19383330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2008.02.002
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