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Activity Dependent Inhibition of AMPA Receptors by Zn(2+)
Zn(2+) has been shown to have a wide range of modulatory effects on neuronal AMPARs. However, the mechanism of modulation is largely unknown. Here we show that Zn(2+) inhibits GluA2(Q) homomeric receptors in an activity- and voltage-dependent manner, indicating a pore block mechanism. The rate of in...
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| 出版年: | J Neurosci |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Society for Neuroscience
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7643288/ https://ncbi.nlm.nih.gov/pubmed/33046551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1481-20.2020 |
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