Activity Dependent Inhibition of AMPA Receptors by Zn(2+)

Zn(2+) has been shown to have a wide range of modulatory effects on neuronal AMPARs. However, the mechanism of modulation is largely unknown. Here we show that Zn(2+) inhibits GluA2(Q) homomeric receptors in an activity- and voltage-dependent manner, indicating a pore block mechanism. The rate of in...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Carrillo, Elisa, Bhatia, Nidhi K., Akimzhanov, Askar M., Jayaraman, Vasanthi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643288/
https://ncbi.nlm.nih.gov/pubmed/33046551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1481-20.2020
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