The PVT1 lncRNA is a novel epigenetic enhancer of MYC, and a promising risk-stratification biomarker in colorectal cancer

Accumulating evidence suggests that dysregulation of transcriptional enhancers plays a significant role in cancer pathogenesis. Herein, we performed a genome-wide discovery of enhancer elements in colorectal cancer (CRC). We identified PVT1 locus as a previously unrecognized transcriptional regulato...

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Bibliografiske detaljer
Udgivet i:Mol Cancer
Main Authors: Shigeyasu, Kunitoshi, Toden, Shusuke, Ozawa, Tsuyoshi, Matsuyama, Takatoshi, Nagasaka, Takeshi, Ishikawa, Toshiaki, Sahoo, Debashis, Ghosh, Pradipta, Uetake, Hiroyuki, Fujiwara, Toshiyoshi, Goel, Ajay
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Letter to the Editor
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643275/
https://ncbi.nlm.nih.gov/pubmed/33148262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-01277-4
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