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Pathomechanisms of ATF6-Associated Cone Photoreceptor Diseases

Activating transcription factor 6 (ATF6) is a key regulator of the unfolded protein response (UPR). In response to endoplasmic reticulum (ER) stress, ATF6 is transported from the ER to the Golgi apparatus where it is cleaved by intramembrane proteolysis, releasing its cytosolic fragment. The cleaved...

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Bibliografiske detaljer
Udgivet i:Adv Exp Med Biol
Main Authors: Chiang, Wei-Chieh Jerry, Kroeger, Heike, Chea, Lulu, Lin, Jonathan H.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643264/
https://ncbi.nlm.nih.gov/pubmed/31884629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-3-030-27378-1_50
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