Sorting nexin 1 loss results in increased oxidative stress and hypertension

Acute renal depletion of sorting nexin 1 (SNX1) in mice results in blunted natriuretic response and hypertension due to impaired dopamine D(5) receptor (D(5)R) activity. We elucidated the molecular mechanisms for these phenotypes in Snx1(−/−) mice. These mice had increased renal expressions of angio...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Yang, Jian, Asico, Laureano D., Beitelshees, Amber L., Feranil, Jun B., Wang, Xiaoyan, Jones, John E., Armando, Ines, Cuevas, Santiago G., Schwartz, Gary L., Gums, John G., Chapman, Arlene B., Turner, Stephen T., Boerwinkle, Eric, Cooper-DeHoff, Rhonda M., Johnson, Julie A., Felder, Robin A., Weinman, Edward J., Zeng, Chunyu, Jose, Pedro A., Villar, Van Anthony M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643053/
https://ncbi.nlm.nih.gov/pubmed/32293069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902448R
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