A role for tubular Na(+)/H(+) exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin

Inhibitors of proximal tubular Na(+)-glucose cotransporter 2 (SGLT2) are natriuretic, and they lower blood pressure. There are reports that the activities of SGLT2 and Na(+)-H(+) exchanger 3 (NHE3) are coordinated. If so, then part of the natriuretic response to an SGLT2 inhibitor is mediated by sup...

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Onishi, Akira, Fu, Yiling, Patel, Rohit, Darshi, Manjula, Crespo-Masip, Maria, Huang, Winnie, Song, Panai, Freeman, Brent, Kim, Young Chul, Soleimani, Manoocher, Sharma, Kumar, Thomson, Scott Culver, Vallon, Volker
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642886/
https://ncbi.nlm.nih.gov/pubmed/32893663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00264.2020
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