Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation

Brugada syndrome (BrS) is one of the major causes of sudden cardiac death in young people, while the underlying mechanisms are not completely understood. Here, we investigated the pathophysiological phenotypes and mechanisms using induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) fro...

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Pubblicato in:Front Cell Dev Biol
Autori principali: Li, Wener, Stauske, Michael, Luo, Xiaojing, Wagner, Stefan, Vollrath, Meike, Mehnert, Carola S., Schubert, Mario, Cyganek, Lukas, Chen, Simin, Hasheminasab, Sayed-Mohammad, Wulf, Gerald, El-Armouche, Ali, Maier, Lars S., Hasenfuss, Gerd, Guan, Kaomei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Cell and Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642519/
https://ncbi.nlm.nih.gov/pubmed/33195263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.592893
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