hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities

Brugada syndrome (BrS) is a rare cardiac rhythm disorder associated with sudden cardiac death. Mutations in the sodium channel gene SCN5A are found in ~20% of cases while mutations in other genes collectively account for <5%. In the remaining patients the genetic defect and the underlying pathoge...

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Udgivet i:Sci Rep
Main Authors: Veerman, Christiaan C., Mengarelli, Isabella, Guan, Kaomei, Stauske, Michael, Barc, Julien, Tan, Hanno L., Wilde, Arthur A. M., Verkerk, Arie O., Bezzina, Connie R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4971529/
https://ncbi.nlm.nih.gov/pubmed/27485484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30967
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