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A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 gua...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7642327/ https://ncbi.nlm.nih.gov/pubmed/33144569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19032-0 |
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