An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants

KRAS is the most frequently mutated oncogene in cancer, yet there is little understanding of how specific KRAS amino acid changes impact tumor initiation, progression, or therapy response. Using high-fidelity CRISPR-based engineering, we created an allelic series of new LSL-Kras mutant mice, reflect...

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Bibliographic Details
Published in:Cancer Discov
Main Authors: Zafra, Maria Paz, Parsons, Marie J, Kim, Jangkyung, Alonso-Curbelo, Direna, Goswami, Sukanya, Schatoff, Emma M, Han, Teng, Katti, Alyna, Fernandez, Maria Teresa Calvo, Wilkinson, John E, Piskounova, Elena, Dow, Lukas E
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642097/
https://ncbi.nlm.nih.gov/pubmed/32792368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0442
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