Merkel Cell Polyomavirus Small T Antigen Activates Non-Canonical NF-κB Signaling to Promote Tumorigenesis

Multiple human polyomaviruses (HPyVs) can infect the skin, but only Merkel Cell Polyomavirus (MCPyV) has been implicated in the development of a cancer, Merkel Cell Carcinoma (MCC). While expression of HPyV6, HPyV7, and MCPyV small T antigens (sT) all induced a senescence associated secretory phenot...

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Pubblicato in:Mol Cancer Res
Autori principali: Zhao, Jiawei, Jia, Yuemeng, Shen, Shunli, Kim, Jiwoong, Wang, Xun, Lee, Eunice, Brownell, Isaac, Cho-Vega, Jeong Hee, Lewis, Cheryl, Homsi, Jade, Sharma, Rohit R., Wang, Richard C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7641980/
https://ncbi.nlm.nih.gov/pubmed/32753470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0587
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